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Regulatory effects of the individual cytokines IL-1β, IL-17, <t>IL-32,</t> TGF-β1, and TNF-α at a range of concentrations on (A) proliferation, (B) HA secretion, and (C) PRG4 secretion by human synoviocytes. Mean ± SEM, n = 5–6; *p < 0.05. HA, hyaluronan; PRG4, proteoglycan 4; IL, interleukin; TGF-β1, transforming growth factor-beta 1; TNF-α, tumor necrosis factor-alpha; SEM, standard error of the mean.
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Regulatory effects of the individual cytokines IL-1β, IL-17, IL-32, TGF-β1, and TNF-α at a range of concentrations on (A) proliferation, (B) HA secretion, and (C) PRG4 secretion by human synoviocytes. Mean ± SEM, n = 5–6; *p < 0.05. HA, hyaluronan; PRG4, proteoglycan 4; IL, interleukin; TGF-β1, transforming growth factor-beta 1; TNF-α, tumor necrosis factor-alpha; SEM, standard error of the mean.

Journal: Tissue Engineering. Part A

Article Title: Interactive Cytokine Regulation of Synoviocyte Lubricant Secretion

doi: 10.1089/ten.tea.2009.0210

Figure Lengend Snippet: Regulatory effects of the individual cytokines IL-1β, IL-17, IL-32, TGF-β1, and TNF-α at a range of concentrations on (A) proliferation, (B) HA secretion, and (C) PRG4 secretion by human synoviocytes. Mean ± SEM, n = 5–6; *p < 0.05. HA, hyaluronan; PRG4, proteoglycan 4; IL, interleukin; TGF-β1, transforming growth factor-beta 1; TNF-α, tumor necrosis factor-alpha; SEM, standard error of the mean.

Article Snippet: 16 – 21 , 25 IL-1β, IL-17 (isoform IL-17A), TGF-β1, and TNF-α were purchased from Peprotech (Rocky Hill, NJ), and IL-32 (isoform not assessed) was purchased from Abnova (Taipei City, Taiwan).

Techniques:

Regulatory effects of different combinations of the cytokines IL-1β, IL-17, IL-32, TGF-β1, and TNF-α (applied at maximum individual stimulation doses) on (A) proliferation, (B) HA secretion, and (C) PRG4 secretion by human synoviocytes. Mean ± SEM, n = 6; *p < 0.05 for individual effect; **p < 0.05 for interactive effect. (+) signs indicate cytokines present in the culture media.

Journal: Tissue Engineering. Part A

Article Title: Interactive Cytokine Regulation of Synoviocyte Lubricant Secretion

doi: 10.1089/ten.tea.2009.0210

Figure Lengend Snippet: Regulatory effects of different combinations of the cytokines IL-1β, IL-17, IL-32, TGF-β1, and TNF-α (applied at maximum individual stimulation doses) on (A) proliferation, (B) HA secretion, and (C) PRG4 secretion by human synoviocytes. Mean ± SEM, n = 6; *p < 0.05 for individual effect; **p < 0.05 for interactive effect. (+) signs indicate cytokines present in the culture media.

Article Snippet: 16 – 21 , 25 IL-1β, IL-17 (isoform IL-17A), TGF-β1, and TNF-α were purchased from Peprotech (Rocky Hill, NJ), and IL-32 (isoform not assessed) was purchased from Abnova (Taipei City, Taiwan).

Techniques: